منابع مشابه
Mutual Prodrugs - a Swot Analysis
Mutual prodrug is a form of prodrug in which two pharmacologically active agents are attached to each other in such a way that each drug acts as a promoiety/carrier for each other and vice versa. The association may be “synergistic” if the carrier shows the same biological action as that of parent drug or may provide “additional” benefit if it shows new pharmacological action which is lacking i...
متن کاملSynthesis and Pharmacological Evaluation of Antiinflammatory Mutual Amide Prodrugs
Nonsteroidal antiinflammatory drugs have been widely used for the management of inflammation, pain and nociception. Gastric intolerance caused by most of the nonsteroidal antiinflammatory drugs used today restricts their use. Several approaches have been proposed to modify the parent nonsteroidal antiinflammatory drugs molecule in order to reduce their gastric toxicity. Oral prodrug approach is...
متن کاملPiroxicam-β-Cyclodextrin: A GI Safer Piroxicam
Although NSAIDs are very effective drugs, their use is associated with a broad spectrum of adverse reactions in the liver, kidney, cardiovascular (CV) system, skin and gut. Gastrointestinal (GI) side effects are the most common and constitute a wide clinical spectrum ranging from dyspepsia, heartburn and abdominal discomfort to more serious events such as peptic ulcer with life-threatening comp...
متن کاملPreparation and Evaluation of Directly Compressible Forms of Mutual Prodrugs of Ibuprofen
Tablets of mutual prodrugs of ibuprofen, i.e, ‘ibuprofen with paracetamol’ and ‘ibuprofen with salicylamide,’ were prepared by direct compression method. The preformulation studies such as flow property, solid state stability at elevated temperatures, solid state stability under different humidity conditions, photolytic stability and compatibility studies of prodrugs with excipients were also p...
متن کاملSynthesis and Biological Evaluation of Mutual Prodrugs of 2- {[3-(trifluoromethyl)phenyl]amino}benzoic Acid
For reducing the gastrointestinal (GI) toxicity associated with flufenamic acid (FA), its carboxylic group was masked by synthesizing its mutual prodrugs with propyphenazone by direct coupling and by using spacer technique. The structures of the synthesized mutual prodrugs (FE and FG) were confirmed by IR, H NMR, C NMR, mass spectroscopy and their purity were established by elemental analysis. ...
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ژورنال
عنوان ژورنال: Acta Scientific Pharmaceutical Sciences
سال: 2019
ISSN: 2581-5423
DOI: 10.31080/asps.2019.03.0305